Objective To assess the clinical efficacy and safety on the combination treatment of colon dialysis and Niaoduqing granule retention-enema in elderly patients with chronic kidney disease（CKD）.Methods From2010 July to 2015 April

142senile patients with CKD were treated by colon dialysis and Niaoduqing granule retention-enema.Before and after the treatment

serum creatinine（Scr）

blood urea nitrogen（BUN）

Cystatin C（CysC）

estimated glomerular filtration rate（eGFR）

and the clinical efficacy and adverse reaction were observed and statistically analyzed.Results Scr and BUN decreased after treatment with significant differences（P<0.05）

while eGFR increased（P<0.05）.The total effective rate was 56.3%.Mild adverse reactions occurred in 5patients（3cases with diarrhea

1case with abdominal distension

1case with anal pain）with 3.5% of adverse reaction ratio.Conclusion The combination treatment of colon dialysis and Niaoduqing granule retention-enema in elderly patients with chronic kidney disease is effective

safe and reliable

which is worth being promoted.