Objectives To investigate factors affecting the quality of life in patients with mammary lobular hyperplasia.Method The subjects selected were 668 cases of females who took physical examination from September 2010 to February 2011 in Liangshan Integrative Hospital of Chinese and Western Medicine.All subjects were surveyed questionnaires designed by the breast specialist and evaluation forms of lobular hyperplasia symptoms and their quality of life was assessed with medical outcomes scale-36 item short-form health survey（SF-36）.The univariate and multivariate factors affecting their quality of life were analyzed.Results Patients with mammary lobular hyperplasia and those with no mammary lobular hyperplasia had no statistical differences of scores in the two dimensions of physiological function（PF）

bodily pain（BP）of SF-36 scale

and had statistically significant differences of scores in the dimensions of physiological role（RP）

general health（GH）

vitality（VT）

social function（SF）

emotional role（RE）and mental health（MH）（P<0.05）.In this study

the differences were statistical significant between scores in dimensions of PF

RP

GH

SF

RE and MH in patients with mammary lobular hyperplasia and norm scores of Sichuan province（P<0.05）.Factors like age（χ2=21.988

P=0.030）

marital status（χ2=12.174

P=0.041）

pregnancy history（χ2=27.260

P=0.021）

abortion frequency（χ2=25.311

P=0.011）

breast-feeding methods（χ2=23.610

P=0.011）were correlated with the incidence of mammary lobular hyperplasia.Without consideration of interaction between factors affecting the quality of life

multivariate analysis showed that factors affecting their quality of life in patients with mammary lobular hyperplasia were sequenced in a decreasing order of stress

abortion frequency

marital status

breast-feeding methods and age.Conclusions Mammary lobular hyperplasia was closely related to age

pregnancy history

abortion frequency and breast-feeding methods of women and stress is the most important factor affecting their quality of life in patients with mammary lobular hyperplasia.