Objective To investigate the level of intervention and mechanism of hydrogen saline on brain injury in rates after cardiopulmonary resuscitation（CPR）.Method 18 male Sprague-Dawley（SD）rats were randomly divided into a control group（Con group）

a resuscitation of spontaneous circulation group（ROSC group）and an intervention group of hydrogen saline（ROSC+ HRS group）

6rats in every group

to establish CPR model and take neurological deficit scores（NDS）after 12 hours of recovery of spontaneous circulation and to measure the water content and the malondialdehyde（MDA）content of rat brain tissues.ResultsROSC+HRS group had a significantly higher NDS and much lower water content and MDA content of brain tissues than ROSC group

the differences were statistically significance（P <0.05）.Conclusion Rats often have neurons necrosis and cerebral edema after CPR and the intervention of hydrogen saline can reduce their brain injury in rats

probably because hydrogen saline may relieve the oxidative injury induced by CPR.