Objective To discuss various risk factors associated with Diabetic Nephropathy（DN）and provide clinical reference for its prevention and treatment.Method To adopt 246 cases of Type 2Diabetes Mellitus（T2DM）patients treated at certain hospital in Pingdingshan as research object.The patients were divided into the study group and comparison group

containing 120（UAER≥20μg/min）and 126 patients respectively

according to their urinary albumin excretion rate（UAER）

revealed test their urinary albumin

and collect relevant indexes for comparative analysis.Results The study result the patients of the two groups marked differences in areas of DM’s course of disease

DM’s family history

hypertension

BMI

smoking

HbA1 c

TG

HDL-C

LDL-C

BUN

and the differences were statistically significant（P<0.05）.Results of multifactor Logistic analysis indicated that hypertension（OR=3.812）

smoking（OR=3.395）

course of disease（OR=3.031）

HbA1c（OR=2.839）

and LDL-C（OR=2.267）are independent risk factors of DN（P<0.05）.Conclusion Actively controlling blood sugar

blood pressure

blood fat

and quitting smoking are crucial measures to prevent the occurrence and aggravation of DN.