Objective To investigate the impact of hormone replacement therapy（HRT）on quality of life in patients with menopausal syndrome.Method 100 cases of women patients with menopausal syndrome received in Changyuan People’s Hospital from January to November 2013 were randomly divided into the study group and the control group

50 cases in each group.Patients in both groups were given conventional health education and the study group also had HRT treatment.After three cycles

all the patients were observed the change of their sex hormones and their quality of life was evaluated with Menopausal Symptoms Rating Scale（Kupperman）

Self-Rating Anxiety Scale（SAS）

Self-Rating Depression Scale（SDS）and Menopause Quality of Life Scale（MENQOL）.Results After the treatment

the level of estradiol（E2）increased

follicle-stimulating hormone（FSH）and luteinizing hormone（LH）decreased in the study group;the difference between before and after treatment was statistically significant（P<0.01）;in the study group

the level of E2 was higher than the control group（P<0.01）

but the levels of FSH and LH were significantly lower than the control group（P<0.01）.Scores of Kupperman

SAS

SDS and MENQOL significantly decreased after the treatment in the study group（P<0.01）and the improvement of quality of life in the study group after treatment was better than that of the control group（P <0.01）.Conclusion HRT can significantly increase the levels of sex hormones in menopausal women and improve their quality of life

worthy of clinical application and further promotion.