LUO Junyuan, ZHANG Hao. The Effect of Terlipressin on the Prevention of Post-Abdominocentesis Circulatory Dysfunction[J]. Health Medicine Research and Practice, 2014,11(4):74-76.
LUO Junyuan, ZHANG Hao. The Effect of Terlipressin on the Prevention of Post-Abdominocentesis Circulatory Dysfunction[J]. Health Medicine Research and Practice, 2014,11(4):74-76.DOI:
特利加压素在预防腹腔穿刺术后循环功能障碍中的作用
摘要
腹水是肝硬化最常见的并发症之一
目前国内外指南均推荐腹腔穿刺大量放液(LVP)为大量腹水首选治疗措施
而腹腔穿刺术后循环功能障碍(PPCD)是LVP后常见的并发症之一。为预防这一并发症
目前临床上常应用静脉输注人血白蛋白进行治疗
但其作为生物制剂
存在价格高昂、潜在的感染风险等问题。特利加压素作为一种人工合成血管加压素已在临床使用多年
有预防PPCD而起到替代白蛋白的作用。本文详细介绍了特利加压素预防PPCD的作用机制及进展
并对其安全性和今后研究方向进行了讨论。
Abstract
Abdominal dropsy is one of the most frequently occurred complications of liver cirrhosis.Presently both domestic and foreign guidance for clinical practices recommend LVP as the preferred treatment for massive ascites
yet PPCD as one of the complications caused by LVP is prone to take place.To prevent this syndrome of complications
the current clinical practice often adopts the method of intravenous injection of human albumin which as a biological product has shortcomings such as high price and potential infection risks.As an artificially compounded vasopressin
terlipressin has seen years of clinical use and has assumed the role of replacing blood albumin as a preventive measure from PPCD.This article expatiates on the functioning mechanism and development of terlipressin in prevention of PPCD
and discuss about its safeness and the future research on it.