ZHANG Yu, YANG Gang-yi. Developments in the Research of the Treatment of Diabetes with Empagliflozin[J]. Health Medicine Research and Practice, 2014,11(3):90-92.
ZHANG Yu, YANG Gang-yi. Developments in the Research of the Treatment of Diabetes with Empagliflozin[J]. Health Medicine Research and Practice, 2014,11(3):90-92.DOI:
Empagliflozin治疗糖尿病的研究进展
摘要
钠葡萄糖协同转运蛋白2(SGLT2)抑制剂是近年来降糖药研究的新热点
其通过抑制肾小管上皮细胞内的主要血糖转运蛋白SGLT2
降低肾小管对葡萄糖的重吸收
从而降低血浆内葡萄糖。临床试验表明新型SGLT2抑制剂Empagliflozin具有良好的降糖效果
能显著降低空腹血糖(FPG)、糖化血红蛋白(HbA1c)
还能显著降低血压和体重
有较好的临床应用前景。
Abstract
Sodium glucose-assisted SGLT2inhibitor is a new hot spot of research on anti-diabetic drugs in recent years.Through suppressing SGLT2
the main blood glucose transporter in the epithelial cells of kidney tubules and hence reducing the re-absorption of glucose by kidney tubules
it serves to lower the amount of glucose inside blood serum.Clinical tests have shown that Empagliflozin
as a new type of SGLT2inhibitor
has a rather good effect on lowering the blood glucose level
and is able to induce a marked decrease of FPG and HbA1c
as well as one’s blood pressure and body weight and is expected to have a bright prospect for clinical application.