Objective To investigate the efficacy of minocycline hydrochloride combining with vitamin A acid cream on the treatment of acne vulgaris and to explore the value of its application.Method 60cases of patients with acne vulgaris were randomly divided into the experimental and control groups to observe the improvement of their skin lesions before and after their treatments and assess the results with scoring method of four grades.Results The effective rate of the experimental group was 71.4% and that of the control group was 38.9%.Conclusion The efficacy of minocycline hydrochloride combining with Vitamin A acid cream on the treatment of acne vulgaris is significant

safe and reliable.It is worthy of clinical application and promotion.