Objective To systematically evaluate the effects of Ursodeoxycholis Acid（UDCA）combined with SAdemetionine（SAMe）and using UDCA alone on the improvement of biochemical index and itchy symptoms in patients with intrahepatic cholestasis of pregnancy（ICP）.Method We used computers to search comparative studies of UDCA with SAMe and UDCA alone on the treatment of ICP from 2003to now in databasesCQVIP

Wanfang data

China Knowledge Resource Integrated Database（CNKI）

China Biology Medicine disc（CBM）

US National Library of Medicine and National Institutes of Health（PubMed）and the Dutch Excerpta Medica Database（Embase）.After screening and data extraction

we did meta-analysis by using RevMan 5.2 software.Results Comparing with using UDCA alone

the treatment of UDCA with SAMe had significant effects on the improvement of itchy symptoms and the reduction of serum total bile acid

total bilirubin

glutamic-pyruvic transaminase and glutamic-oxaloacetic transaminase.Conclusion The treatment of UDCA combined with SAMe has a better effect than using UDCA alone on the improvement of itchy symptoms and serum biochemical index.