Objective To understand the results of different doses of hepatitis B vaccine in order provide references for rational vaccination.Method We divided into 3 groups 360 students who had been vaccinated with hepatitis B vaccine without HBsAb and 469 students who weren’t vaccinated with negative for HBsAb.They were vaccinated 5 μg

10 μg

20 μg respectively.They were under close inspection to observe the situation of turning positive for an HBsAb.Results The students not vaccinate before have been vaccinated 3 different doses

and positive rates of HBsAb were 85.26%

87.82%

88.54% respectively

which is of no statistical significance（P>0.05）.The students vaccinated with hepatitis B vaccine without HBsAb have been vaccinated 3 different doses

and positive rates of HBsAb were 34.17%

50.83%

61.67% respectively

which is of statistical significance（P<0.01）.Conclusion To the cases with immune tolerance

the positive rates of HBsAb rise with the increasing of the doses.So 10 μg is suggested for revaccination.And 5 μg is suitable for common cases.