Objective To investigate the relationship of the methylenetetrahydrofolate reductase（MTHFR） C677T gene polymorphism to recurrent abortion（RA）.Method MTHFRC677T genotype were analyzed by the technique of Polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） in recurrent abortion group（60 cases） and control group（60 cases）.Results MTHFR677TT genotype frequency and T allele frequencies of RA pregnant women and villi were higher than control group（p<0.05）.There was a significant difference of the distribution of the 3 genotypes between the recurrent abortion group and the control group.Embryo villi of recurrent abortion MTHFR677CT+TT genotype frequencies were higher than control group（p<0.05）.Conclusion RA patients and embryo villi with the mutation MTHFR677TT each other are related to RA.