Objective To better understand the infection situation of Hepatitis B virus among universities and take the effective preventing ways to control this infection. Method Collecting data in blood test （ALT

HBsAg） from physical body check for all the freshmen in Shanghai Institute of Foreign Trade from 2003 to 2006. Results 9 875 samples have been evaluated during these 4 years period. There are 184 samples are showed positive in HBsAg which takes 1.86% in total. More specifically

there is 3.77% within students from other cities 1.36% within all the Shanghai students

and it shows a significant difference（p<0.01）. 2.04% within all the male students and 1.78% within all the female students are shown positive in HBsAg. There isn’t significant diffcrence（p>0.05）. Conclusion The percetage of positive in HBsAg for freshmen is lower than before. It is necessary to take the aggressive action to prevent the infection of Hepatitis B virus for the freshmen.