Objective      To study the correlation between IL-1α-889 polymorphism and susceptibility to chronic periodontitis (CP).       Methods      Papers on correlation between IL-1α-889 polymorphism and susceptibility to CP were systematically retrieved from CBM

CNKI

PUBMED

MEDLINE and EMBASE. Academic level of papers included in this study was assessed according to the Newcastle-Ottawa Scale (NOS). Meta-analysis of the correlation between IL-1α-889 polymorphism and susceptibility to CP was carried out using the Review Manager (Version 5.1.2) and Stata (Version 11.0)

respectively. Pooled odds ratio (OR) and 95%CI for the correlation between IL-1α-889 polymorphisms and susceptibility to CP were evaluated. Publication bias in the papers was tested by funnel plot

Egger’s regression test and Begg’s test

respectively. Sensitivity analysis was performed for the exclusion of papers not conforming to HWE

followed by a repeat Meta-analysis.       Results      Nineteen papers covering 1 949 cases of chronic periodontitis and 1 455 controls were included in the meta-analysis. Our study showed that IL-1α-889 polymorphism was correlated with the susceptibility to CP in T allele model (OR=1.41

95%CI=1.17-1.70

P=0.000 3)

T/T model (OR=1.58

95%CI=1.20-2.10

P=0.001)

dominant gene model (OR=1.61

95%CI=1.27-2.05

P0.000 1)

and recessive gene model (OR=1.39

95%CI=1.07-1.79

P=0.01).       Conclusion      IL-1α-889 polymorphism is correlated with the susceptibility to CP. The susceptibility to CP increases in T allele carriers.