Objective   To investigate the effect of Xinfukang oral liquid on the cardiac function and levels of energy-rich phosphates in pressure overload-induced left ventricular hypertrophy rats.    Methods   Totally 120 SD rats were randomly divided into 3 groups

sham operation group (SH) (n=40)

coarctation of abdominal aorta model group (CAA) (n=40)

and model and Xinfukang oral liquid treatment gro

up (XFK) (n=40). Parameters of cardiac function

levels of energy-rich phosphates and morphological changes of the myocardial mitochondria were observed at the 6th and 8th week after the treatment.    Results   In CAA group at the 6th week after operation

the cardiac function parameters (LVMI and LVEDP) were increased and +dp/dt

max

was decreased

while ATP and ADP were decreased and AMP was increased in comparison with SH group (P0.01). These changes were much obvious in 8 weeks (P0.01

P0.05). Compared with those of CAA group

the parameters of heart function and energy-rich phosphates (ATP

ADP

AMP

TAN) in XFK group were improved significantly (P0.01) at the 6th and 8th week. In XFK group

the parameters of heart function and energy-rich phosphates were much better at 8th week than at 6th week (P0.01

P0.05). The morphological change of mitochondria was lesser in XFK group than in CAA group.    Conclusion   XFK oral liquid significantly improves the myocardial energy metabolism in pressure overload rats and protects the function of myocardial mitochondria.