Objective    To evaluate the value of preoperative lateralized

1

H-magnetic resonance spectroscopy (

1

HMRS) on temporal lobe epilepsy (TLE).     Methods   

1

HMRS of 45 patients with unilateral TLE confirmed surgically and pathologically were retrospectively analyzed

and 10 patients without systemic disease and neurological symptoms served as control. The N-Acetyl L-Aspartic acid (NAA)

Creatine (Cr)

Choline (Cho)

NAA/Cr

NAA/Cho

NAA/(Cr＋Cho) were calculated respectively and compared among the lesion group

the contralateral group and control group.     Results    NAA

Cr

Cho

NAA/Cr

NAA/Cho

NAA/(Cr＋Cho) were

respectively

(52.31±12.78) ppm

(40.36±8.06) ppm

(42.78±10.43) ppm

(1.29±0.15)

(1.24±0.14) and (0.63±0.05) for the lesion group

and (58.04±13.25) ppm

(40.49±10.02) ppm

(42.42±10.68) ppm

(1.45±0.16)

(1.39±0.13)

(0.70±0.05) for contralateral group

and (59.86±11.28) ppm

(39.00±7.10) ppm

(40.43±6.61) ppm

(1.55±0.19)

(1.49±0.12)

(0.76±0.06) for control group. There was significant difference in NAA

NAA/Cr

NAA/Cho

NAA/(Cr＋Cho) between hemispheres with and without lesions (P0.05). The coefficient of variation of NAA/(Cr＋Cho) ranged from 7.04% to 7.93%

and the diagnostic accuracy rate and specificity was 86.67% and 100% respectively when NAA/(Cr＋Cho) ratio was 0.65 and the margin was 0.07.     Conclusion   

1

HMRS can quantify biochemical metabolic disorders of temporal lobe and is a complementary modality for evaluating TLE.