Objective    To explore the effects of aqueous extract from Lycopsis orientalis linn (AELO) on algaesthesis and healing of skin ulcer in mice.     Methods    AELO was prepared with decocting method. Analgesic actions of AELO were determined using writhing response induced by acetic acid and hot plate. Capillary permeability was measured with Evans blue colorimetric method in peritonitis model induced by acetic acid. Acetic acid was also used to induce skin ulcer in mice. The PGE

2

content in ulcer tissue was measured colorimetrically.     Results    AELO (10

20

40 g/kg) inhibited writhing response

increased the pain threshold

and decreased the capillary permeability significantly. Local application of AELO markedly pro

moted the ulcer healing and decreased PGE

2

content in ulcer tissue in comparison of control group.     Conclusion    AELO can exert analgesic and healing effect in skin ulcer

the mechanism of which involves capillary permeability decrease and PGE

2

production.