Objective    To identify the promoting function of soluble a proliferation-induced ligand (sAPRIL) to the proliferation of HeLa cells and its possible mechanism.     Methods    The proliferation stimulating effect of sAPRIL to HeLa cells was detected by Brdu. RT-PCR was performed to identify the expression of sAPRIL receptors on HeLa cells.     Results    sAPRIL had positive effect to promote the proliferation of HeLa cells. HeLa cells could express sAPRIL receptors HSPG1 and HSPG2 but not BCMA

TACI or HSPG4.     Conclusion    sAPRIL can effectively promote the proliferation of HeLa cells

which might be associated with HSPG1 and HSPG2.