Objective    To investigate the role of losartan in AT2-R mediated renal protective effects in renovascular hypertension rat.     Methods    Male SD rats were divided into sham group and renovascular hypertension group in which Goldblatt methods were performed. The two groups were intragastically administered with losartan (respectively 0

10

20

30 mg·kg

-1

·d

-1

) for 6 weeks. Then renal function was measured

the AT2-R expression in the non-ischemic kidney and the AngⅡ contents in non-ischemic kidney and plasma were determined.     Results    In renovascular hypertension rats

especially in the contralateral

non-ischemic

kidney

the expression of AT2-R protein were up-regulated. Losartan increased the AngⅡ contents in non-ischemic kidney and plasma

mediated the natriuretic/diuretic effect and renal protective effect in renovascular hypertension rat and increased the expression of renal AT2-R.     Conclusion    In renovascular hypertension rat

losartan mediates renal natriuretic/diuretic effect and protects renal function through up-regulating AT2-R in kidney.