Autophagy is an important cell self repair mechanism in human body. It can maintain cell homeostasis by decomposing and recycling harmful substances and Organelle in cells. It plays an important role in various aspects such as cellular immunity，inflammatory response，and cell survival，including clearing foreign objects，regulating inflammatory response，maintaining cell survival，and regulating immune signaling. Whether innate or adaptive immunity，autophagy plays an important role in the process of chronic lung inflammation. The abnormal regulation of autophagy has been proven to be closely related to the occurrence and development of various chronic lung diseases. Studying autophagy can help reveal the mechanism of occurrence and development of lung diseases，and provide important ideas for disease prevention and treatment，as well as research and development of new drugs. Here we discussed the role of autophagy in chronic inflammation of the lungs，such as asthma，chronic obstructive pulmonary disease，and tuberculosis.