Dietary factors affecting metastasis after breast cancer surgery based on nested case-control study

ZHU Yanxi; LEI Xiuhui; LEI Yuqian; ZHOU Yu; HE Junfang; TANG Yan

doi:10.3969/j.issn.2096-3351.2024.02.012

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Dietary factors affecting metastasis after breast cancer surgery based on nested case-control study

更新时间：2024-04-11

- Dietary factors affecting metastasis after breast cancer surgery based on nested case-control study
- Journal of Southwest Medical University Vol. 47, Issue 2, Pages: 157-161(2024)
- 作者机构：
  
  1. 西南医科大学公共卫生学院,泸州,646000
  2. 西南医科大学立普社,泸州,646000
  3. 重庆市九龙坡区疾病预防控制中心传防科,重庆,400000
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2096-3351.2024.02.012
  CLC：
- Published：2024，
  
  Published Online：20 March 2024，
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ZHU Yanxi, LEI Xiuhui, LEI Yuqian, et al. Dietary factors affecting metastasis after breast cancer surgery based on nested case-control study. [J]. Journal of Southwest Medical University 47(2):157-161(2024)
DOI：

ZHU Yanxi, LEI Xiuhui, LEI Yuqian, et al. Dietary factors affecting metastasis after breast cancer surgery based on nested case-control study. [J]. Journal of Southwest Medical University 47(2):157-161(2024) DOI： 10.3969/j.issn.2096-3351.2024.02.012.

摘要

目的探讨膳食因素与乳腺癌术后转移的关系，为该人群的饮食干预提供依据。方法基于2013 年西南医科大学附属医院乳腺外科建立的乳腺癌队列，以2013 年1 月至2018 年12 月随访发现的乳腺癌转移者140 例为病例组，按照年龄±3 岁，对照组与病例组行乳腺癌根治手术时间差应该控制在一个月范围内，手术方式和术后辅助治疗方案等一致，排除术前已经出现复发转移或合并其他器官肿瘤疾病的患者等1∶1 匹配，以同期未发生乳腺癌转移的患者140 例为对照组，比较两组的病理资料、食物频率等，使用SPSS 20.0 进行单因素分析和多因素logistic回归分析筛选出导致乳腺癌术后转移的独立危险因素。结果单因素分析结果显示肉类、蔬菜类、水果类的摄入量在转移组和对照组之间的差异具有统计学意义（P < 0.001）。多因素条件Logistic 回归模型结果显示每日食用少于推荐摄入量的蔬菜[OR 值（95% CI）为5.068（1.873~ 13.716），P < 0.001]、每日食用少于推荐摄入量的水果[OR 值（95% CI）为8.119（2.721 ~ 24.228），P < 0.001]、每日食用超过推荐摄入量的肉类[OR 值（95% CI）为5.009（1.847 ~ 13.585），P < 0.05]均是乳腺癌患者术后发生转移的独立危险因素。结论每日食用少于推荐摄入量的蔬菜（<200 g）和水果（< 300 g），每日食用超过推荐摄入量的肉类（> 75 g）均是乳腺癌术后转移的独立危险因素，影响患者的预后。

Abstract

Objective To investigate the relationship between dietary factors and postoperative breast cancer metastasis and to provide a basis for dietary intervention in this population. Methods Based on the breast cancer cohort established in the Breast Cancer Surgery Department of Southwest Medical University Affiliated Hospital in 2013

a case-control study was conducted. The case group consisted of 140 breast cancer patients with metastasis identified during follow-up from January 2013 to December 2018. The control group was matched on age within a range of ±3 years and underwent breast cancer radical surgery within a one-month difference in timing compared to the case group. The surgical procedures

postoperative adjuvant therapy plans

and exclusion criteria（such as patients with preoperative recurrence

metastasis

or concurrent tumors in other organs）were consistent between the two groups. A total of 140 patients who did not experience breast cancer metastasis during the same period were selected as the control group. Pathological data and dietary frequency were compared between the two groups. SPSS 20.0 was used for univariate analysis and multivariate logistic regression analysis to identify independent risk factors associated with postoperative metastasis of breast cancer. Results The results of univariate analysis showed statistically significant differences in the intake of meat

vegetables

and fruits between the metastasis group and the control group（P < 0.001）. The results of multifactorial conditional logistic regression modeling showed that daily consumption of less than the recommended intake of vegetables [OR（95% CI）5.068（1.873-13.716）

P < 0.001]

daily consumption of less than the recommended intake of fruits [OR（95% CI）8.119（2.721-24.228）

P < 0.001] and daily consumption of meat more than the recommended intake [OR（95% CI）5.009（1.847 ~ 13.585）

P < 0.05] were independent risk factors for the development of metastasis in postoperative breast cancer patients. Conclusion Daily consumption of less than the recommended intake of vegetables（< 200 g）and fruits（< 300 g）and daily consumption of more than the recommended intake of meat（> 75 g）were both independent risk factors for postoperative metastasis of breast cancer

which affected the prognosis of patients.

关键词

乳腺癌膳食因素肿瘤预后肿瘤转移

Keywords

Breast cancerDietary factorsTumor prognosisTumor metastasis

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