Bone resorption

formation and homeostasis maintenance are based on osteogenic and osteoclastic phenomenon

which include the regulation of a variety of factors. HIF-1α

as a marker of hypoxia

has been confirmed participating in a variety of process related to osteogenesis and osteoclast. And various vivo and in vitro hypoxia models have further revealed that HIF-1α can regulate bone physiology. These studies provide direct or indirect evidence that HIF-1α regulates osteogenic and osteoclastic events

but the effects of HIF-1α on osteogenesis and osteoclasty have not been systematically summarized. This review summarized the mechanism of regulation of HIF-1α on osteogenesis and osteoclasty and its participation in relevant clinical events. HIF-1α directly participates in osteogenesis and osteoclasty mainly through combing with the hypoxia response element (HRE) of osteogenesis related gene and osteoclast related gene under hypoxia. In addition

HIF-1α can also achieve the energy demand of osteogenic and osteoclastic events by enhancing glycolysis. But at the same time

the acidified environment will further stimulate the actvition of osteoclasts. Through the above review

we found that the two different events of osteogenesis and osteoclast regulated by HIF-1α may be closely related to the duration and concentration of hypoxia

and the acidification degree of glycolysis under different oxygen conditions

mediated by HIF-1α

may be the key factors that determine the trend of osteogenesis and osteoclast. We believe that hypoxia duration

as a part of "hypoxia dose"

should have an important impact on bone physiology

which needs more attention in future research. At the same time

in the state of continuous hypoxia

the transformation of HIF subtypes is also worthy of more in-depth study on the impact of bone physiology.Therefore

this article focuses on the effect of HIF-1αon osteogenesis and osteoclasis process under hypoxia

and provide a theoretical basis for the regulation mechanisms of bone physiological changes under hypoxia.