Myocardial infarction （MI） has long been the leading cause of death in coronary heart disease

and its features include irreversible myocardial cell death and restricted blood flow supply. Exosomes

extracellular vesicles loaded with biological cargoes such as RNA

proteins

and lipids

are important mediators of paracrine secretion and play an important role in myocardial repair and signaling after MI. After MI

the exosomes derived from cardiomyocytes can partly reflect the pathological state of the heart

and may aggravate the heart injury

but it may also have some therapeutic effects. Therefore

this article will review the recent studies on the regulatory effects and mechanisms of cardiomyocyte derived exosomes on the heart after MI

in order to further understand the mechanism of exosomes in cardiac pathological injury

and provide reference for future exosome-related clinical studies.