Objective To explore the effect of pain specialist nurse-led multidisciplinary collaboration model on the quality of life of patients with cancer pain at home.Methods A total of 468 patients with cancer pain who were discharged from the oncology depart⁃ ment and pain department of a tertiary hospital in Nanchong City for home treatment were selected and randomly divided into a control group and an intervention group，of which 219 cases were in the control group and 228 cases in the intervention group.The control group underwent routine discharge follow-up.the intervention group adopted a multidisciplinary collaboration model led by pain spe⁃ cialist nurses to manage cancer pain patients treated at home.The intervention time was 3 months.The main indicator was the patients’ quality of life，and the secondary indicators were the side effects of cancer pain drugs，medication Adherence，anxiety and depression scores，and pain scores.Results The quality of life score and medication compliance of the intervention group were higher than those of the control group（P < 0.001）.The side effects of cancer pain drugs，anxiety and depression scores，and pain scores in the intervention group were lower than those in the control group（P < 0.001）.Conclusion The management mode of multidisciplinary collaboration led by pain specialist nurses in the discharge management of cancer pain patients had a positive impact on improving the quality of life，medication compliance，side effects of cancer pain drugs，anxiety and depression scores，and pain scores of patients.