Objective To evaluate the quality and anti-alcoholic liver injury effects of Penthorum chinense Pursh effervescent tablet（PCPET）.Method The quality evaluation of PCPET was conducted through identification，inspection，and content determina⁃ tion.An acute alcoholic liver injury model was established in mice by alcohol gavage.The effects of PCPET on mouse liver index ，se⁃ rum alanine aminotransferase（ALT），aspartate aminotransferase（AST），low-density protein cholesterol（LDL-C），liver homogenate superoxide dismutase（SOD），prototype glutathione（GSH）and triglyceride（TG）levels were measured，as well as pathological exami⁃ nation.Results PCPET had an average weight of 0.48 g，weight difference of 2%，gas yield of 6.5 mL，hardness of 33.60 N，brittle de⁃ gree of 1.0%，average disintegration time limit of 3′43′′，pH value of 4.82 ~ 5.15，and contained 0.76 mg/g of quercetin.PCPET de⁃ creased the liver index，ALT，AST，LDL-C，and TG content and increased SOD and GSH activity of damaged hepatocytes.Pathological sections showed that PCPET effectively improved the impaired hepatocyte morphology and reduced inflammatory infiltration.Conclusion PCPET meets the requirements of the Chinese Pharmacopoeia 2020 for effervescent tablets and had a good protective effect on acute alcoholic liver injury.These findings provided direction for in-depth research and development of Penthorum chinense Pursh.