Pathogenesis，screening of high-risk population，and the treatment of pancreatic cancer

MA Xinchen; GUO Jinsheng; LIU Liang

doi:10.3969/j.issn.2096-3351.2023.02.006

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Pathogenesis，screening of high-risk population，and the treatment of pancreatic cancer

更新时间：2023-05-05

- Pathogenesis，screening of high-risk population，and the treatment of pancreatic cancer
- Journal of Southwest Medical University Vol. 46, Issue 2, Pages: 116-121(2023)
- 作者机构：
  
  1. 中南大学湘雅医学院,长沙,410000
  2. 复旦大学附属中山医院消化科,上海,200032
  3. 复旦大学附属中山医院胰腺外科,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2096-3351.2023.02.006
  CLC：
- Published：2023，
  
  Published Online：20 March 2023，
扫描看全文
MA Xinchen, GUO Jinsheng, LIU Liang. Pathogenesis，screening of high-risk population，and the treatment of pancreatic cancer. [J]. Journal of Southwest Medical University 46(2):116-121(2023)
DOI：

MA Xinchen, GUO Jinsheng, LIU Liang. Pathogenesis，screening of high-risk population，and the treatment of pancreatic cancer. [J]. Journal of Southwest Medical University 46(2):116-121(2023) DOI： 10.3969/j.issn.2096-3351.2023.02.006.

摘要

胰腺导管腺癌（ pancreatic ductal adenocarcinoma，PDAC）由于常进展到晚期才被诊断并对化疗具有耐药性，因此是一种临床上具有挑战性的癌症。然而，最近对PDAC 的生物学研究进展揭示了早期检测和靶向治疗PDAC 的新机会。本文就PDAC 的发病机制研究进展进行评述，包括肿瘤细胞的分子改变、肿瘤微环境的细胞改变和人群水平的危险因素。本文还分析了PDAC 的早期检测、高危人群的筛查以及治疗方法，可供临床借鉴。

Abstract

Pancreatic ductal adenocarcinoma（PDAC）is a clinically challenging cancer because it is often diagnosed at an advanced stage and resistant to chemotherapy. However，recent advances in biological research on PDAC have revealed new opportunities for early diagnosis and targeted therapy of PDAC. This article reviewed the progress of pathogenesis of PDAC，including molecular changes in tumor cells，cellular changes in tumor microenvironment，and population-level risk factors. The early detection of PDAC， screening and treatment of high-risk population were also discussed for clincal reference.

关键词

胰腺导管腺癌发生机制危险因素筛查早期诊断治疗

Keywords

Pancreatic ductal adenocarcinomaPathogenesisRisk factorsScreeningEarly diagnosisTreatment

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WEI Qian

GUO Jinsheng

QIAN Keli

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HUANG Shuli

Related Institution

Department of Gastroenterology and Hapatology,Zhong Shan Hospital,Fudan University,Shanghai Institute of Liver Diseases

Department of Infection Control，The First Affiliated Hospital of Chongqing Medical University

Department of Infectious Diseases，The First Affiliated Hospital of Chongqing Medical University

Department of Paediatrics，The First Affiliated Hospital of Henan University of T..M，Zhengzhou

School of Public Health，Southwest Medical University

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