Objective To investigate the effects of dexmedetomidine combined with dezocine onperioperative sedation，postoperative pain，inflamatory factors and T lymphocyte subsets in elders undergoing hip surgery under spinal anesthesia. Methods 60 elders with ASA status Ⅱ~Ⅲ scheduled hip surgerywere divided into DD group and MS group，with 30 cases in each group. All patients were performed spinal anesthesia. Dexmedetomidine and dezocine were used in DD group while midazolam and sufentanilwere used in MS group for auxiliary anesthesia. Ramsay sedation scores and VAS scores were observed at 2

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and 24 hours after operation. by flow cytometry and the blood levels of IL-6 and TNF-α were detected by enzyme-linked immunoassay. Results There were no significant differences in Ramsay sedation scoresbetween the two groups at all time points （P > 0.05）; VAS scores at 8 h and 12 h after operation in DD group were significantly lower than those in MS group，（P < 0.05）; The blood levels of IL-6 and TNF-α at 2 h，12 h and 24 h after operation in DD group were significantly lower than those in MS group，（P < 0.05）; The levels of CD3+ cells，CD4+ cells and CD4+/CD8+ ratio in DD group were significantly higher than those in MS group，（P < 0.05）. Conclusion Dexmetomidine combined with dezocine as auxiliary anesthesia for spinal anesthesia in elders undergoing hip surgery could achieve good sedative effects，relieve postoperative pain，reduce postoperative blood levels of IL-6，TNF-α and relive the decreases of postoperative blood percentage of CD3+cells，CD4+cell and the ratio of CD4+/CD8+.