Objective To explore the potential pharmacological mechanism of Gushi Fang in the treatment of osteonecrosis of the femoral head（ONFH）. Methods Firstly，TCMSP database was used to retrieve the active ingredients of Gushi Fang，and the search re⁃sults were screened according to the bioavailability and drug-like properties. Then，the Genecard and OMIM databases were used to re⁃trieve the disease targets of ONFH.Venn map was drawn for potential targets of Gushi Fang in the treatment of ONFH via R language. The compound-target-disease network was drawn by Cytoscape software. The STRING database was used to make a protein interaction network diagram. Finally，GO biological function and KEGG signal pathway enrichment analysis were performed by R language. Re⁃sults There were 96 active ingredients，121 cross genes with ONFH，and 58 signal pathways in Gushi Fang. IL-17，TNF，and P13K-Akt signal pathways were mainly involved in regulation. According to the network diagram，the key components of Gushi Fang were si⁃tosterol，stigmasterol，quercetin and β-sitosterol，and the key targets were IL-6，AKT1，VEGFA，MAPK3 and JUN. Conclusion Gushi Fang played an anti-inflammatory role and regulated the osteoclast/osteoclast ratio through multiple genes and signaling pathways，thus achieving the therapeutic effect of ONFH，which reflected the characteristics of multi-components and multi-targets of Gushi Fang，and also provided a theoretical basis for clinical application of Gushi Fang.