Objective To explore the mechanism of Xuanbai Chengqi Decoction "FeiChangTongZhi" in the treatment of chronic obstructive pulmonary disease（COPD）by using network pharmacology and molecular docking. Methods The effective components and corresponding targets of Xuanbai Chengqi Decoction were retrieved and downloaded by the traditional Chinese medicine system pharmacology analysis platform（TCMSP）. The targets of COPD were retrieved and downloaded from five databases including Gen⁃ ecards. Venn online software was used to obtain the common targets of drugs and diseases，and Cytoscape 3.7.2 software was used to con⁃ struct the "active ingredient-intersection target-disease" network diagram. The String database was used to draw the protein interaction （PPI）network，and the Cytonca in Cytoscape was used to score the COPD targets，and the core target proteins of the network were ob⁃ tained，and molecular docking was conducted with the screened potential active components of Xuanbai Chengqi Decoction one by one. The GO function and KEGG pathway enrichment analysis of the effective targets were conducted using the David database. Results A total of 45 effective compounds of Xuanbai Chengqi Decoction were screened out，and 88 effective targets were identified. Eighty drugdisease common targets were obtained by Venn diagram，and PPI network and other comprehensive analysis found that MYC，AR，JUN， ESR1，PGR and TP53 might be the key targets of Xuanbai Chengqi Decoction in the treatment of COPD. Conclusion Xuanbai Chengqi Decoction took "fei chang tong zhi" as the core theory，and played an important role in the treatment of COPD through multicomponents， multi-targets and multi-pathways，which laid a foundation for the in-depth study of active ingredients and related mecha⁃ nisms，and provided new ideas for experimental and clinical medication.