Pathogenesis and protective strategies of chronic obstructive pulmonary disease based on mitochondrial dynamics

WEN Fuqiang; SHEN Yongchun

doi:10.3969/j.issn.2096-3351.2022.05.001

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Pathogenesis and protective strategies of chronic obstructive pulmonary disease based on mitochondrial dynamics

更新时间：2023-05-05

- Pathogenesis and protective strategies of chronic obstructive pulmonary disease based on mitochondrial dynamics
- Journal of Southwest Medical University Vol. 45, Issue 5, Pages: 369-372(2022)
- 作者机构：
  
  四川大学华西医院呼吸与危重症医学科/生物治疗国家重点实验室呼吸病学研究室,成都,610041
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2096-3351.2022.05.001
  CLC：
- Published：2022，
  
  Published Online：20 September 2022，
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WEN Fuqiang, SHEN Yongchun. Pathogenesis and protective strategies of chronic obstructive pulmonary disease based on mitochondrial dynamics. [J]. Journal of Southwest Medical University 45(5):369-372(2022)
DOI：

WEN Fuqiang, SHEN Yongchun. Pathogenesis and protective strategies of chronic obstructive pulmonary disease based on mitochondrial dynamics. [J]. Journal of Southwest Medical University 45(5):369-372(2022) DOI： 10.3969/j.issn.2096-3351.2022.05.001.

摘要

慢性阻塞性肺疾病是严重影响健康的慢性气道疾病，其发病机制较为复杂，为其临床诊治带来了挑战。不断有研究表明线粒体动力学在慢性阻塞性肺疾病发病机制中发挥着重要作用，本文将重点介绍慢性阻塞性肺疾病病人中的线粒体动力学异常，香烟对线粒体动力学的影响，Mfn2/Opa1/Drp1等线粒体分裂融合蛋白在慢性阻塞性肺疾病中的发病机制，并探索基于线粒体动力学的慢性阻塞性肺疾病保护策略，以期为慢性阻塞性肺疾病的防治带来新的思路。

Abstract

Chronic obstructive pulmonary disease（COPD）is a chronic airway disease which seriously endangers health. The pathogenesis of COPD is complicated，which brings challenges for its clinical diagnosis and treatment. A growing number of studies sug⁃gest that mitochondrial dynamics play an important role in COPD，and this article aims to introduce the abnormal mitochondrial dynam⁃ics in patients with COPD，the effects of cigarette smoke on mitochondrial dynamics，the role of Mfn2/Opa1/Drp1 in COPD，and poten⁃tial therapeutic strategy based on mitochondrial dynamics，in order to bring new ideas for the prevention and treatment of COPD.

关键词

线粒体动力学慢性阻塞性肺疾病香烟

Keywords

Mitochondrial dynamicsChronic obstructive pulmonary diseaseCigarette smoke

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