Prediction of new on-set postoperative atrial fibrillation after cardiac surgery by MiRNA-499

doi:10.3969/j.issn.2096-3351.2022.04.011

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Prediction of new on-set postoperative atrial fibrillation after cardiac surgery by MiRNA-499

更新时间：2023-05-05

- Prediction of new on-set postoperative atrial fibrillation after cardiac surgery by MiRNA-499
- Journal of Southwest Medical University Vol. 45, Issue 4, Pages: 337-339(2022)
- 作者机构：
  
  淮安市第一人民医院，南京医科大学附属淮安第一医院心脏外科,淮安,223300
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2096-3351.2022.04.011
  CLC：
- Published：2022，
  
  Published Online：20 July 2022，
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Prediction of new on-set postoperative atrial fibrillation after cardiac surgery by MiRNA-499. [J]. Journal of Southwest Medical University 45(4):337-339(2022)
DOI：

Prediction of new on-set postoperative atrial fibrillation after cardiac surgery by MiRNA-499. [J]. Journal of Southwest Medical University 45(4):337-339(2022) DOI： 10.3969/j.issn.2096-3351.2022.04.011.

摘要

目的研究心脏术后病人外周血miRNA-499的表达对心脏手术后新发心房颤动(postoperative atrial fibrillation，POAF)的预测作用及对胺碘酮治疗的反应。方法采用实时定量聚合酶链反应(RT-PCR)检测109例POAF病人和96例非POAF病人外周血miRNA-499及其靶mRNA的表达，同时结合胺碘酮治疗分析其预后。结果 miRNA-499在POAF病人中呈明显高表达（1.86 ± 0.35 vs. 2.77 ± 0.51，4.23 ± 1.37，P < 0.05）。与非POAF组相比，胺碘酮治疗阴性组[胺碘酮(－)组]与胺碘酮治疗阳性组[胺碘酮(＋)组]miRNA-499表达量均上调，且miR-499在胺碘酮(－)组上调明显高于胺碘酮(＋)组患者(2.77 ± 0.51 vs. 4.23 ± 1.37，P = 0.005)。ROC曲线分析显示miRNA-499可作为潜在的POAF胺碘酮治疗反应生物标志物 (AUC = 0.72，P = 0.006)。结论 miRNA-499表达量增加可能有助于临床判断心脏术后POAF的发生，同时还可以预测POAF对胺碘酮治疗的转归及预后。

Abstract

Objective To investigate the expression of miRNA-499 in peripheral blood of patients after cardiac surgery，and to confirm its predictive role on postoperative atrial fibrillation (POAF) and the response to amiodarone treatment. Methods Real-time quantitative polymerase chain reaction (RT-PCR) was used to detect the expression of miRNA-499 and its target mRNA in peripheral blood of 109 POAF patients and 96 non-POAF patients. At the same time，combined with amiodarone treatment，the prognosis was analyzed. Results miRNA-499 was significantly overexpressed in POAF patients （1.86 ± 0.35 vs. 2.77 ± 0.51，4.23 ± 1.37，P < 0.05）. Compared to non-POAF group，the expression of miRNA-499 was up-regulated in the amiodarone (-) group and the amiodarone (+) group，and the up-regulation of miR499 in the amiodarone (-) group was significantly higher than that in the amiodarone (+) group (2.77 ± 0.51 vs. 4.23 ± 1.37，P = 0.005). ROC curve analysis showed that miRNA-499 could be used as a potential biomarker of POAF amiodarone treatment response (AUC = 0.72，P = 0.006). Conclusion The increased expression of miRNA-499 may contribute to the clinical judgment of the occurrence of POAF after cardiac surgery，as well as predict the outcome and prognosis of amiodarone treatment on POAF patients.

关键词

心脏手术心房颤动microRNA-499

Keywords

Cardiac SurgeryAtrial fibrillationMicroRNA-499

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