Prediction of gastrointestinal bleeding by blood routine in children with Henoch-Schonlein purpura

doi:10.3969/j.issn.2096-3351.2022.04.009

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Prediction of gastrointestinal bleeding by blood routine in children with Henoch-Schonlein purpura

更新时间：2023-05-05

- Prediction of gastrointestinal bleeding by blood routine in children with Henoch-Schonlein purpura
- Journal of Southwest Medical University Vol. 45, Issue 4, Pages: 328-331(2022)
- 作者机构：
  
  川北医学院附属医院儿科,南充,637000
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2096-3351.2022.04.009
  CLC：
- Published：2022，
  
  Published Online：20 July 2022，
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Prediction of gastrointestinal bleeding by blood routine in children with Henoch-Schonlein purpura. [J]. Journal of Southwest Medical University 45(4):328-331(2022)
DOI：

Prediction of gastrointestinal bleeding by blood routine in children with Henoch-Schonlein purpura. [J]. Journal of Southwest Medical University 45(4):328-331(2022) DOI： 10.3969/j.issn.2096-3351.2022.04.009.

摘要

目的探讨血常规预测过敏性紫癜（Henoch-Schonlein purpura，HSP）患儿消化道出血指标的价值。方法回顾性分析2016年1月至2020年5月间于我院住院的HSP的患儿，对白细胞计数（WBC）、中性粒细胞计数（GR）、淋巴细胞计数（LY）、血小板计数（PLT）、平均血小板体积（MPV）、中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）进行了评价，通过专业知识并保证数据拟合优良性分析标志物与HSP消化道出血的相关性。结果本研究共纳入308例HSP患儿，其中155例（50.3%）有胃肠道病变，74例（24%）有胃肠道出血，经拟合模型的选择及Logistic回归分析，GR及PLR为HSP消化道出血的潜在危险因素，GR的最佳截断值为7.72，敏感度和特异度分别为54.1%、 69.7%；PLR的最佳截断值为161.03，敏感度和特异度分别为54.1%、71.4%。结论 GR及PLR可能是HSP患儿消化道出血的潜在危险预测指标。

Abstract

Objective To explore the value of blood routine in predicting gastrointestinal bleeding in children with Henoch-Schonlein purpura (HSP). Methods Retrospectively analyzed the children with HSP who were hospitalized in our hospital from January 2016 to May 2020. The white blood cell count (WBC)，neutrophil count (GR)，lymphocyte count (LY)，platelets count (PLT)，mean platelet volume (MPV)，neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were evaluated. The correlation between markers and HSP gastrointestinal bleeding was analyzed with expertise and good data fitting. Results A total of 308 HSP patients were enrolled in this study，of which 155 (50.3%) had gastrointestinal lesions and 74 (24%) had gastrointestinal bleeding. Selection of fitted models and Logistic regression analysis showed that GY and PLR were potential risk factors for HSP gastrointestinal bleeding. The best cut-off value of GY was 7.72，and the sensitivity and specificity were 54.1% and 69.7%，respectively； the best cut-off value of PLR was 161.03，and the sensitivity and specificity were 54.1% and 71.4%，respectively. Conclusion GR and PLR may be the potential predictors of gastrointestinal bleeding in children with HSP.

关键词

过敏性紫癜胃肠道出血儿童白细胞血小板

Keywords

Henoch-Schonlein purpuraGastrointestinal bleedingChildrenWhite blood cellsPlatelet

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