Objective To study the active ingredients of Xiangsha Liujun Pill and to explore the possible mechanism of delayed gastric emptying caused by gastroparesis based on network pharmacology. Methods The active ingredients and target proteins of Xiangsha Liujun Pill were collected through TCMSP，TCMID database and related literatures. The targets of gastroparesis and delayed gastric emptying were collected through the GeneCards database. The “ingredients-targets-pathways” and protein-protein interaction network were constructed from the above data. The results were subject to GO and KEGG pathway enrichment analyses and were preliminarily verified by molecular docking method. Results A total of 105 effective compounds were screened out，which played roles by regulating 92 potential targets including interleukin-6，caspase-3，and epidermal growth factor receptor，with tumor necrosis factor，AGE-RAGE，and other related signaling pathways involved. The molecular docking results showed good affinity. Conclusion The active ingredients including quercetin，baicalein and β-sitosterol in Xiangsha Liujun Pill may be the material basis for the prevention and treatment of delayed gastric emptying caused by gastroparesis，with anti-infection and anti-apoptosis pathways involved. The study will provide a reference for subsequent related theoretical and clinical studies.