The molecular mechanism and clinical application of vitamin D3/vitamin D receptor in inflammatory bowel diseases

YU Mengli; YU Chaohui

doi:10.3969/j.issn.2096-3351.2022.01.002

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The molecular mechanism and clinical application of vitamin D3/vitamin D receptor in inflammatory bowel diseases

更新时间：2023-05-05

- The molecular mechanism and clinical application of vitamin D3/vitamin D receptor in inflammatory bowel diseases
- Journal of Southwest Medical University Vol. 45, Issue 1, Pages: 7-12(2022)
- 作者机构：
  
  浙江大学医学院附属第一医院消化内科,杭州,310000
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2096-3351.2022.01.002
  CLC：
- Published：2022，
  
  Published Online：20 February 2022，
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YU Mengli, YU Chaohui. The molecular mechanism and clinical application of vitamin D3/vitamin D receptor in inflammatory bowel diseases. [J]. Journal of Southwest Medical University 45(1):7-12(2022)
DOI：

YU Mengli, YU Chaohui. The molecular mechanism and clinical application of vitamin D3/vitamin D receptor in inflammatory bowel diseases. [J]. Journal of Southwest Medical University 45(1):7-12(2022) DOI： 10.3969/j.issn.2096-3351.2022.01.002.

摘要

炎症性肠病（inflammatory bowel disease， IBD）是一组病因不明的慢性复发性胃肠道免疫疾病的统称，临床上主要分为克罗恩病（Crohn’s?disease， CD）和溃疡性结肠炎（ulcerative colitis，UC）两种类型。维生素D受体（vitamin D receptor， VDR）是细胞核激素受体超家族的一员，在体内由配体维生素D3（vitamin D3， VD3）激活后调控多种不同的信号通路。研究发现，肠道VDR的表达在IBD的发生发展中具有重要作用。VDR可以通过影响肠道炎症稳态、肠上皮屏障功能、肠道免疫反应与肠道菌群调节等多方面影响IBD的发生发展。临床上给予IBD患者一定剂量的膳食VD补充可以改善患者的生活质量并降低复发率。因此，VD/VDR通路与IBD的相关基础研究具有重要的临床应用价值。

Abstract

Inflammatory bowel diseases （IBDs） are a group of chronic relapsing gastrointestinal immune disorders with unknown etiology. Clinically， IBDs mainly include Crohn’s disease and ulcerative colitis. Vitamin D receptor （VDR）， a member of the nuclear hormone receptor superfamily， is activated by vitamin D3 （VD3） to regulate a variety of signal pathways. Studies have shown that VDR expression in the intestine has a crucial role in the development and progression of IBDs by regulating intestinal inflammation homeostasis， intestinal epithelial barrier function， intestinal immune response， and gut microbiota. Clinically， dietary supplementation with VD can improve patients’ quality of life and reduce the recurrence rate of IBDs. Therefore， basic research on the VD/VDR pathway and IBDs has important clinical values.

关键词

炎症性肠病维生素D受体维生素D3

Keywords

Inflammatory bowel diseaseVitamin D receptorVitamin D3

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