Mechanism of liver cancer-associated zinc finger protein/transcription factor disorders and their clinical value

doi:10.3969/j.issn.2096-3351.2021.06.001

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Mechanism of liver cancer-associated zinc finger protein/transcription factor disorders and their clinical value

更新时间：2023-04-16

- Mechanism of liver cancer-associated zinc finger protein/transcription factor disorders and their clinical value
- Journal of Southwest Medical University Vol. 44, Issue 6, Pages: 585-592(2021)
- 作者机构：
  
  1. 南通大学附属医院临床医学研究中心,南通,226001
  2. 南通大学医学院免疫学系,南通,226001
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2096-3351.2021.06.001
  CLC：
- Published：2021，
  
  Published Online：20 November 2021，
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Mechanism of liver cancer-associated zinc finger protein/transcription factor disorders and their clinical value. [J]. Journal of Southwest Medical University 44(6):585-592(2021)
DOI：

Mechanism of liver cancer-associated zinc finger protein/transcription factor disorders and their clinical value. [J]. Journal of Southwest Medical University 44(6):585-592(2021) DOI： 10.3969/j.issn.2096-3351.2021.06.001.

摘要

肝细胞癌（hepatocellularcarcinoma，HCC）是我国常见恶性肿瘤之一，其发生发展机制复杂且尚未完全阐明。锌指蛋白家族（zincfingerproteinfamily，ZNFs）是人类基因组中最大的转录因子家族，越来越多临床和基础研究证据显示ZNFs及其Krüppel-like转录因子（KLFs）在HCC发生、发展中异常表达，发挥促癌或抑癌作用，其中部分因子有望成为HCC的新标志物和治疗靶点。本文述评了肝癌ZNFs/KLFs表达及其临床价值研究的新进展。

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China

with its mechanism of development and progression remaining to be fully elucidated. Zinc finger protein family (ZNFs) is the largest transcription factor family in human genome; more and more clinical and basic research evidences have shown that abnormal ZNFs/Krüppel-like factors (KLFs) expression was observed during the development and pro⁃gression of HCC

playing a cancer-promoting or-inhibiting role; some of the factors show promise for new tumor bio⁃markers or therapeutic targets for HCC. This article reviews the recent research advances in ZNFs/KLFs expression in HCC and their clinical value.

关键词

锌指蛋白肝细胞癌调控机制肿瘤标志物

Keywords

Zinc finger proteinHepatocellular carcinomaRegulatory mechanismTumor biomarker

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Related Author

CHEN Heng-kai

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Related Institution

Departement of Hepatobiliary Surgery，Mengchao Hepatobiliary Hospital of Fujian Medical University

The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province

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