Correlation between lncRNA and miRNA and theirs effects on cancer prognosis: A meta-analysis

doi:10.3969/j.issn.2096-3351.2021.05.020

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Correlation between lncRNA and miRNA and theirs effects on cancer prognosis: A meta-analysis

更新时间：2023-04-16

- Correlation between lncRNA and miRNA and theirs effects on cancer prognosis: A meta-analysis
- Journal of Southwest Medical University Vol. 44, Issue 5, Pages: 551-559(2021)
- 作者机构：
  
  1. 西南医科大学公共卫生学院,泸州,646000
  2. 西南医科大学中西医结合学院,泸州,646000
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2096-3351.2021.05.020
  CLC：
- Published：2021，
  
  Published Online：20 September 2021，
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Correlation between lncRNA and miRNA and theirs effects on cancer prognosis: A meta-analysis. [J]. Journal of Southwest Medical University 44(5):551-559(2021)
DOI：

Correlation between lncRNA and miRNA and theirs effects on cancer prognosis: A meta-analysis. [J]. Journal of Southwest Medical University 44(5):551-559(2021) DOI： 10.3969/j.issn.2096-3351.2021.05.020.

摘要

目的总结与癌症预后有关的长链非编码RNA（lncRNA）和微小RNA（miRNA）并分析其相关性，以评价ln⁃cRNA和miRNA在癌症预后及相关性方面的现状。方法检索PubMed、Embase、WebofScience、CNKI和Cochrane图书馆数据库，收集队列研究文献并使用纽卡斯尔-渥太华量表进行偏倚风险评估，使用R4.0.2分析风险比（HR）和相关系数r。结果共纳入27篇针对2967例患者的研究。森林图显示，高表达的lncRNA与总体生存率预后不良有关，合并的HR为2.49（95％CI：2.04~3.03，P<0.001）；lncRNA与miRNA呈负相关，合并的r值为-0.68（95%CI：-0.8~-0.56）。结论非编码RNA对于癌症预后可能是预测因子，且lncRNA与miRNA之间存在相关性，可能共同发挥作用影响癌症预后。

Abstract

Objective To analyze the relationship between long non-coding RNA（lncRNA），microRNA （miRNA），and the prognosis of cancers. Methods We searched PubMed，Embase，Web of Science，China National Knowledge Infrastructure and the Cochrane Library for relevant cohort studies，used the Newcastle-Ottawa Scale to assess the risk of bias，and employed R 4.0.2 to analyze hazard ratio（HR）and correlation coefficient（r）. Results A total of 27 studies involving 2 967 patients were included. The forest plots showed that high expression of lncRNA was correlated with a poor overall survival rate，with a pooled HR of 2.49（95% confidence interval [CI]：2.04 to 3.03，P < 0.001）；there was a negative correlation between lncRNA and miRNA，with a pooled r of-0.68（95% CI：-0.8 to-0.56）. Conclusion LncRNA may be a predictor for the prognosis of cancer. There is a correlation be⁃tween lncRNA and miRNA，and they may work together to affect the prognosis of cancer.

关键词

长链非编码RNA微小RNA癌症预后相互作用

Keywords

Long non-coding RNAMicroRNACancer prognosisInteraction

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