Objective To provide ideas and directions for the basic research on pancreatic cancer treatment by elaborating on the current main strategy of constructing a nano-drug delivery system based on extracellular ma⁃trix for the treatment of pancreatic cancer. Methods The relevant domestic and foreign journal articles were consult⁃ed to sort out the research ideas and results and summarize the advantages and disadvantages. Results The pancre⁃atic cancer treatment based on extracellular matrix can be used as an effective therapeutic strategy in addition to di⁃rectly targeting cancer cells. By regulating the remodeling of extracellular matrix components to increase drug pene⁃tration，and disrupting the microenvironment on which pancreatic cancer cells rely for survival，the synergistic na⁃no-drug delivery system can show excellent drug penetration promotion and better therapeutic effect. Conclusion Extracellular matrix components of pancreatic cancer are complex and diverse，and have close interactions with can⁃cer cells and non-cancer cells. Ablation of extracellular matrix components promotes drug entry into the core of tu⁃mor and enhances the therapeutic efficacy，but may also lead to further spread and metastasis of cancer. In addition， the excessive accumulation of extracellular matrix components distorts the normal structure of pancreatic cancer tis⁃sues，resulting in different characteristics from other solid tumors，namely，the compressed vascular system leads to interstitial hypovascularity. Therefore，many aspects should be taken into consideration in the design of therapeutic strategies in this area.