Research advances in heat shock 70-kDa protein 6 (HSPA6)

SHEN Shi-yi; SONG Bing-hui; FU Jun-jiang

doi:10.3969/j.issn.2096-3351.2021.05.007

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Research advances in heat shock 70-kDa protein 6 (HSPA6)

更新时间：2023-04-16

- Research advances in heat shock 70-kDa protein 6 (HSPA6)
- Journal of Southwest Medical University Vol. 44, Issue 5, Pages: 460-468(2021)
- 作者机构：
  
  西南医科大学基础研究中心表观遗传与肿瘤四川省高校重点实验室,泸州,646000
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2096-3351.2021.05.007
  CLC：
- Published：2021，
  
  Published Online：20 September 2021，
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SHEN Shi-yi, SONG Bing-hui, FU Jun-jiang. Research advances in heat shock 70-kDa protein 6 (HSPA6). [J]. Journal of Southwest Medical University 44(5):460-468(2021)
DOI：

SHEN Shi-yi, SONG Bing-hui, FU Jun-jiang. Research advances in heat shock 70-kDa protein 6 (HSPA6). [J]. Journal of Southwest Medical University 44(5):460-468(2021) DOI： 10.3969/j.issn.2096-3351.2021.05.007.

摘要

热休克蛋白A6（heatshock70-kDaprotein6，HSPA6）属于HSP70家族，在哺乳动物谱系中部分保守的可诱导的70-kD蛋白。HSPA6基因位于人类染色体1q23.3上，包含两个重要结构领域：N末端的核苷酸结合域（NBD）和C末端的底物结合域（SBD）。目前研究发现HSPA6对肿瘤的发生、发展既有抑制作用，也有促进作用，在非肿瘤疾病的罹患中也扮演着多种重要角色。HSPA6已日渐成为研究的热点，但其作用机制仍未明确。本文对HSPA6蛋白的结构、表达、功能及其在肿瘤中的研究进展、可能的作用机制及未来展望作一概述。

Abstract

Heat shock 70-kDa protein 6 (HSPA6) belongs to the HSP70 family and is a partially conserved inducible 70-kD protein in mammals. The HSPA6 gene locates in the human chromosome 1q23.3 and contains two important structural domains: the N-terminal nucleotide-binding domain (NBD) and the C-terminal substrate-bind⁃ing domain (SBD). At present

studies have found that HSPA6 both inhibits and promotes the development and pro⁃gression of tumors; meanwhile

it also plays a variety of important roles in the pathogenesis of non-tumor diseases. HSPA6 is becoming a hot spot of research

but its mechanism of action is still unclear. This article reviews the struc⁃ture

expression

and function of HSPA6 protein

the research advances in the role of HSPA6 protein in tumor

and its possible mechanism of action and prospect.

关键词

热休克70-kDa蛋白A6结构域肿瘤抗肿瘤活性机制

Keywords

HSPA6DomainTumorAntitumor activityMechanism

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Related Author

审校

何志巍

综述

马音晓

黄恩雨

FU Jun-jiang

LIU Xiao-yan

WEI Chun-li

Related Institution

American Cancer Research Institute of Guangdong Medical University，，China

The Research Center for Preclinical Medicine，Key Laboratory of Epigenetics and Oncology of Universities，South?west Medical University

Department of Stomatology of Yellow River Central Hospital of Yellow River Water Conservancy Commission

Department of Oral and Maxillofacial Surgery,Nanchong Central Hospital,the Second Clinical Medical College Of North Sichuan Medical College

School of Pharmacy, Southwest Medical University

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