Plasminogen activator inhibitor-1 (PAI-1) is a member of the evolutionarily conserved serine pro⁃tease inhibitor family. The increased expression of PAI-1 leads to pathological diseases such as vascular diseases

obesity

and metabolic syndrome. Senescence-associated secretory phenotype (SASP) mediates tissue damage and plays a role in adipose tissue dysfunction. Chronic inflammation in adipose tissue is associated with the development of metabolic diseases

including obesity

insulin resistance

and type 2 diabetes. PAI-1 plays a vital role in adipose tissue physiology

glucose metabolism

insulin secretion and sensitivity

inflammation

and macrophage chemotaxis. This article reviews the possible role of PAI-1

as one of the SASP markers

and speculates the potential role of PAI-1 in adipose tissue senescence and inflammatory macrophage infiltration in obesity.