Clinical features and influencing factors for coronavirus disease 2019-related liver injury

doi:10.3969/j.issn.2096-3351.2021.04.010

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Clinical features and influencing factors for coronavirus disease 2019-related liver injury

更新时间：2023-04-16

- Clinical features and influencing factors for coronavirus disease 2019-related liver injury
- Journal of Southwest Medical University Vol. 44, Issue 4, Pages: 358-362(2021)
- 作者机构：
  
  山东省胸科医院结核科（济南 2550013
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2096-3351.2021.04.010
  CLC：
- Published：2021，
  
  Published Online：20 July 2021，
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Clinical features and influencing factors for coronavirus disease 2019-related liver injury. [J]. Journal of Southwest Medical University 44(4):358-362(2021)
DOI：

Clinical features and influencing factors for coronavirus disease 2019-related liver injury. [J]. Journal of Southwest Medical University 44(4):358-362(2021) DOI： 10.3969/j.issn.2096-3351.2021.04.010.

摘要

目的分析2019新型冠状病毒肺炎相关肝功能损伤情况及影响因素，为临床治疗提供参考。方法纳入山东省胸科医院收治的2019新型冠状病毒肺炎病例68例，分析肝功能损伤患者的临床特点及影响因素。结果68例确诊病例中，轻型、普通型患者56例，出现肝功能损伤22例；重型、危重型患者12例，出现肝功能损伤11例。肝功能损伤组患者体重指数、乳酸脱氢酶（LDH）、α羟基丁酸脱氢酶（HBDH）显著高于肝功能正常组（P<0.05），淋巴细胞计数显著低于肝功能正常组（P<0.05）。多因素分析：超重或肥胖、重型、危重型是肝功能损伤的独立危险因素（OR=0.324，95%CI：0.110~0.956；OR=0.085，95%CI：0.010~0.731）。结论超重或肥胖、重型、危重型是影响2019新型冠状病毒肺炎相关肝功能损伤的独立危险因素，在治疗过程中应加强对超重或肥胖、重型、危重型者肝功能指标检测、评估和治疗。

Abstract

Objective To investigate the clinical features and influencing factors for coronavirus disease 2019（COVID-19）-related liver injury，and to provide a reference for clinical treatment. Methods A total of 68 pa⁃tients with COVID-19 who were admitted to Shandong Provincial Chest Hospital were enrolled，and their clinical features and related influencing factors were analyzed. Results Among the 68 patients with confirmed COVID-19， 56 had mild-or common-type COVID-19（among whom 22 had liver injury）and 12 had severe-or critical-type COVID-19（among whom 11 had liver injury）. Compared with the patients with normal liver function，the patients with liver injury had significantly higher body mass index，lactate dehydrogenase，and α-hydroxybutyrate dehydro⁃genase（P < 0.05）and a significantly lower lymphocyte count（P < 0.05）. The multivariate analysis showed that overweight/obesity（odds ratio [OR]=0.324，95% confidence interval [CI]：0.110~0.956）and severe/critical type （OR=0.085，95% CI：0.010~0.731）were independent risk factors for liver injury. Conclusion Overweight/obe⁃sity and severe/critical type are independent risk factors for COVID-19-related liver injury，and it is necessary to strengthen the measurement，evaluation，and treatment of liver function parameters in patients with overweight/obe⁃sity and severe/critical-type COVID-19.

关键词

2019新型冠状病毒肺炎肝功能损伤谷丙转氨酶谷草转氨酶肥胖

Keywords

Coronavirus disease 2019Liver injuryAlanine aminotransferaseAspartate amino⁃transferaseObesity

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