ObjectiveTo investigate the value of ultrasound in screening fetal congenital structural malformations.MethodsThe clinical data of 10 133 parturients with birth outcomes in Beijing Obstetrics and Gynecology Hospital and other Maternal and Child Health Hospital in different districts of Beijing were retrospectively analyzed.The positive rates of different structural malformations screened by ultrasound and the positive rates of different pregnancy stage were analyzed.ResultsAmong the 10 133 cases

a total of 214 cases of congenital birth defects（16 cases of complex malformations）were found

and a total of 230 malformations were found.Among these

totally 92 cases（95 deformities） of fetal structural malformations were detected by prenatal ultrasound screening

with a detection rate of 0.91%

and 31 cases（50 deformities）of postnatal ultrasound were diagnosed

with a detection rate of 1.21%（123 cases）.A total of 13 cases were misdiagnosed by ultrasound

with a misdiagnosis rate of 0.13%.Totally 120 cases of structural malformations were misdiagnosed by ultrasound

with a misdiagnosis rate of 1.18%.The diagnostic accuracy of life-threatening fetal structural malformations was100%.The accuracy

sensitivity and specificity of ultrasound in screening congenital structural malformations were 90.44%

61.19%and 99.87%

respectively.The detection rate of fetal malformation in early pregnancy

middle pregnancy and late pregnancy was 2.17%

69.57%and 28.26%

respectively

with the highest detection rate in the middle pregnancy（P<0.05）.ConclusionUltrasound is a direct and effective method for the screening of congenital structural malformations

especially in the middle pregnancy with the highest detection rate.However

several non-life-threatening fetal structural abnormalities are missed diagnosis.