Preparation of targeted anticancer nanoparticles and evaluation of the efficacy of enhanced synergistic sonodynamic/starvation combined therapy

ZHANG Ruo; ZHANG Liang; HUANG Ju; YANG Yang; WANG Zhigang

doi:10.16245/j.cnki.issn1008-6978.2021.05.001

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Preparation of targeted anticancer nanoparticles and evaluation of the efficacy of enhanced synergistic sonodynamic/starvation combined therapy

更新时间：2021-10-08

- Preparation of targeted anticancer nanoparticles and evaluation of the efficacy of enhanced synergistic sonodynamic/starvation combined therapy
- Journal of Clinical Ultrasound in Medicine Vol. 23, Issue 5, Pages: 321-326(2021)
- 作者机构：
  
  1. 重庆医科大学附属第二医院超声科
  2. 重庆医科大学附属第三医院超声科
- 作者简介：
- 基金信息：
- DOI：10.16245/j.cnki.issn1008-6978.2021.05.001
  CLC： R730.5
- Published：2021，
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ZHANG Ruo, ZHANG Liang, HUANG Ju, et al. Preparation of targeted anticancer nanoparticles and evaluation of the efficacy of enhanced synergistic sonodynamic/starvation combined therapy. [J]. Journal of Clinical Ultrasound in Medicine 23(5):321-326(2021)
DOI：

ZHANG Ruo, ZHANG Liang, HUANG Ju, et al. Preparation of targeted anticancer nanoparticles and evaluation of the efficacy of enhanced synergistic sonodynamic/starvation combined therapy. [J]. Journal of Clinical Ultrasound in Medicine 23(5):321-326(2021) DOI： 10.16245/j.cnki.issn1008-6978.2021.05.001.

摘要

目的制备一种载IR780及葡萄糖氧化酶（GOx）的多功能纳米粒

研究其主动靶向能力

并评估其增强体外光声成像及声动力（SDT）/饥饿联合治疗的效果。方法通过双乳化法制备载IR780及GOx的聚乳酸-羟基乙酸共聚物纳米粒（IG@P纳米粒）。检测IG@P纳米粒的理化性质

观察其增强体外光声成像的效果

并评估该纳米粒对鼠源性乳腺癌4T1细胞的靶向能力及体外SDT/饥饿联合治疗效果。结果制备的IG@P纳米粒呈大小均一的球形

平均粒径为（248.1±24.3）nm

且仍保留GOx的催化活性。纳米粒与细胞共孵育后

在鼠源性乳腺癌4T1细胞内可观察到明显的纳米粒聚集

体外治疗结果显示IG@P纳米粒对肿瘤细胞具有显著的杀伤作用

肿瘤细胞存活率为（17.5±9.2）%。结论成功制备了具有肿瘤靶向作用的IG@P多功能纳米粒

其不仅可用于增强光声成像

还可增效SDT/饥饿联合治疗。

Abstract

ObjectiveTo synthesize an IR780 and glucose oxidase（GOx）-based multifunctional nanoparticles

and to examine its abilities of active targeting

photoacoustic（PA）imaging and synergistic sonodynamic（SDT）/starvation therapy.MethodsIR780 and GOx-based PLGA nanoparticles（IG@P NPs）was prepared by double emulsion method.The characteristic properties

targeting ability

PA imaging effect and therapeutic outcome of IG@P NPs were evaluated.ResultsThe average diameters of IG@P NPs with uniform spherical appearance were about（248.1±24.3）nm.And the catalytic activity of GOx in NPs was remained.After co-incubated with 4T1 cells

significant nanoparticles aggregation was observed.In vitro antitumor study showed that IG@P NPs possessed excellent antitumor capability and the survival rate of tumor cells was （17.5±9.2）%.ConclusionMultifunctional IG@P NPs with tumor targeting performance have been successfully prepared

which can be used in PA imaging and SDT/starvation combined therapy.

关键词

声动力治疗饥饿治疗纳米粒靶向性

Keywords

Sonodynamic therapyStarvation therapyNanoparticlesTargeting

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