Objective To explore the clinical application value of three-dimensional speckle tracking（3D-STI）technique in evaluating the right ventricular myocardial function in breast cancer patients with anthracycline chemotherapeutic.Methods A total of 46 patients with breast cancer treated with anthracycline were enrolled

they were examined by 3D-STI and

99m

Tc-MIBI and

18

F-FDG of binuclein imaging 1 d before chemotherapy

and 1 d after 2

4 and 6 cycles of chemotherapy.The systolic blood flow velocity and displacement of tricuspid annulus（S

TAPSE）

right ventricular area change fraction（RV-FAC）

left/right ventricular end-diastolic volume（LV-V/RV-V）

left ventricular ejection fraction（LVEF）

right ventricular global longitudinal strain（RVGLS）

circumferential strain（RVGCS）

radial strain（RVGRS）and area strain（RVGAS）were measured.The differences of the above parameters at different time points were compared

and Pearson correlation analysis was used to analyze the correlation among RVGLS

RVGAS and conventional echocardiographic indexes and 3D-STI parameters. ROC curves was drawn to evaluate the diagnostic efficiency of RVGLS and RVGAS in predicting right ventricular dysfunction.Results Before and after 2

4

6 cycles of chemotherapy

the comparison of S

TAPSE

RV-FAC

RV-V

LV-V

LVEF had no significant difference.3D-STI examination showed the RVGLS was decreased after 2

4

6 cycles of chemotherapy compared with that before chemotherapy

and the RVGAS was decreased after 4

6 cycles of chemotherapy compared with that before chemotherapy（all P

<

0.05）.Compared with 2 cycles of chemotherapy

the RVGLS and RVGAS were decreased after 4 and 6 cycles of chemotherapy（all P

<

0.05）.The RVGLS and RVGAS after 6 cycles of chemotherapy were lower than those of 4 cycles of chemotherapy（both P

<

0.05）.Correlation analysis showed that RVGLS was correlated with S

TAPSE

RV-FAC

RV-V

LV-V

LVEF

RVGCS

RVGRS and RVGAS（r=0.260

0.267

0.202

0.210

0.165

0.188

0.286

0.199

0.848

all P

<

0.05）

RVGAS was also associated with S

TAPSE

RV-FAC

RV-V

LV-V

LVEF

RVGLS

RVGCS

RVGRS（all P

<

0.05）. ROC curve analysis showed that taking RVGLS

<

16.99% and RVGAS

<

20.57% as cutoff values

the sensitivity and specificity of predicting right ventricular dysfunction were 73.1%

96.2% and 90.0%

65.0%

respectively

the area under the curve were 0.879 and 0.830

respectively.Conclusion 3D-STI has high value in the evaluation of right ventricular myocardial function in breast cancer patients with anthracycline chemotherapy

it can be used as an important monitoring method for early right cardiac function changes.