Objective To evaluate the relationship between the ultrasound contrast grading of neovascularization in carotid atherosclerotic plaques and blood lipid in patients with coronary heart disease（CHD）.Methods A total of 146 patients with carotid plaque formation were selected

79 of them were identified as CHD（CHD group

105 plaques） by coronary angiography

and 67 were non CHD patients（control group

97 plaques）. All of them were examined by carotid ultrasound

carotid contrast enhanced ultrasound and blood lipid test. The correlation between ultrasound contrast grading of neovascularization in carotid atherosclerotic plaques and blood lipid level was analyzed.Results The grade of carotid plaques were mainly grade Ⅱ and grade Ⅲ（73 plaques）in CHD group

while in control group

those were grade 0 and grade Ⅰ（61 plaques）.There was significant difference in the distribution of carotid plaques grading between the two groups（P<0.05）.Total cholesterol（TC）

low density lipoprotein cholesterol（LDL-C）

small and dense low density lipoprotein cholesterol（sdLDL-C）of CHD group were higher than those of control group（all P<0.05）.Correlation analysis showed that ultrasound contrast grading of neovascularization in carotid atherosclerotic plaques was positively correlated with TC

sdLDL-C in CHD group（r=0.512

0.681

both P<0.05）.Conclusion Contrast-enhanced ultrasound can well reflect the angiographic grading of neovascularization in plaques of CHD patients

the angiographic grading of neovascularization in plaques have a certain correlation with blood lipid level.