Objectives To investigate the cavitation modulation of VINNO 70 integrated ultrasound theranostic system and its acoustic parameters measurement

as well as the adaptive variable focus technique for targeted microbubble destruction.Methods The frequency（f）

pulse length（PL）

pulse repetition frequency（PRF）were measured by thin film hydrophone method to verify their consistency with the values displayed by the instrument.Similarly

the peak negative pressure（PNP）in the region of interest（ROI）2 cm and 5 cm away from the transducer surface were emphatically measured to calculate the corresponding mechanical index（MI）

and they were compared with the values displayed by instrument. Microbubble destruction was recorded to analyze the adaptive variable focus technique.Results The values of f

PL and PRF of linear array probe X4-12L and convex array probe S1-8C were consistent with those displayed by the instrument. There was obvious difference between MI and the value displayed by the instrument（58%～267%）

and MI was affected by f and the distance to the transducer.The adaptive variable focus technique had weakly focusing performance

and the microbubble in ROI was obviously broken.Conclusion VINNO 70 integrated ultrasound theranostic system can accurately regulate several cavitation related parameters

and the adaptive variable focus technique can target and break the microbubbles in ROI. Due to the difference between the measured value and the displayed value of MI

the measured value should be prevail considered during treatment.