Application value of Kwak TI-RADS and BRAF<sup>V600E</sup> gene mutation detection in thyroid nodules with indeterminate cytological results

ZHONG Lichang; MA Fang; GU Liping

doi:10.16245/j.cnki.issn1008-6978.2021.01.010

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Application value of Kwak TI-RADS and BRAF^V600E gene mutation detection in thyroid nodules with indeterminate cytological results

更新时间：2021-10-08

- Application value of Kwak TI-RADS and BRAF^V600E gene mutation detection in thyroid nodules with indeterminate cytological results
- Journal of Clinical Ultrasound in Medicine Vol. 23, Issue 1, Pages: 36-39(2021)
- 作者机构：
  
  上海交通大学附属第六人民医院超声科
- 作者简介：
- 基金信息：
- DOI：10.16245/j.cnki.issn1008-6978.2021.01.010
  CLC： R581;R445.1
- Published：2021，
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[1]钟李长,马方,谷丽萍.Kwak TI-RADS分类联合BRAF~(V600E)基因突变检测对不确定意义细胞学诊断结果的甲状腺结节的诊断价值[J].临床超声医学杂志,2021,23(01):36-39.

ZHONG Lichang, MA Fang, GU Liping. Application value of Kwak TI-RADS and BRAF^V600E gene mutation detection in thyroid nodules with indeterminate cytological results. [J]. Journal of Clinical Ultrasound in Medicine 23(1):36-39(2021)
[1]钟李长,马方,谷丽萍.Kwak TI-RADS分类联合BRAF~(V600E)基因突变检测对不确定意义细胞学诊断结果的甲状腺结节的诊断价值[J].临床超声医学杂志,2021,23(01):36-39. DOI： 10.16245/j.cnki.issn1008-6978.2021.01.010.

ZHONG Lichang, MA Fang, GU Liping. Application value of Kwak TI-RADS and BRAF^V600E gene mutation detection in thyroid nodules with indeterminate cytological results. [J]. Journal of Clinical Ultrasound in Medicine 23(1):36-39(2021) DOI： 10.16245/j.cnki.issn1008-6978.2021.01.010.

摘要

目的探讨Kwak TI-RADS分类联合BRAFV600E基因突变检测诊断不确定意义细胞学诊断结果的甲状腺结节良恶性的应用价值。方法选取于我院行细针穿刺细胞学诊断且结果为不确定意义的76例甲状腺结节患者

均行常规超声和BRAFV600E基因突变检测

以手术病理结果或临床随访为标准

绘制受试者工作特征（ROC）曲线

计算并比较Kwak TI-RADS分类与BRAFV600E基因突变检测鉴别不确定意义细胞学诊断结果的甲状腺结节良恶性的诊断效能。结果纳入的76例甲状腺结节均经手术病理或临床随访证实

包括恶性结节50例

良性结节26例。Kwak TI-RADS分类诊断甲状腺恶性结节的敏感性78.0%

特异性76.9%

准确率77.6%

曲线下面积0.775;BRAFV600E基因突变检测的诊断敏感性62.0%

特异性100%

准确率75.0%

曲线下面积0.810;二者联合诊断的敏感性88.0%

特异性84.6%

准确率86.8%

曲线下面积0.873

与两者单独应用比较

差异均无统计学意义。结论 Kwak TI-RADS分类联合BRAFV600E基因突变检测可以一定程度上提高对不确定意义细胞学诊断结果的甲状腺结节良恶性的诊断效能

有一定的临床价值。

Abstract

ObjectiveTo evaluate the diagnostic value of Kwak TI-RADS and BRAFV600 Egene mutation detection forindeterminate thyroid nodules.MethodsA total of 76 patients with 76 thyroid nodules were selected

which were initiallydiagnosed as indeterminate thyroids nodules

who were underwent ultrasound and BRAFV600 Egene mutation detection. Thereceiver operating characteristic（ROC）curve based on the surgical pathological results or clinical follow-up was drawn

and thediagnostic efficacy of Kwak TI-RADS classification and BRAFV600 Egene mutation detection in differentiating benign andmalignant thyroid nodules with uncertain cytological results was calculated and compared.ResultsSeventy-six cases of thyroidnodules were confirmed by surgical pathology or clinical follow-up

including 50 cases of malignant nodules and 26 cases ofbenign nodules.The sensitivity

specificity

accuracy and area under the curve of BRAFV600 Egene mutation were 62.0%

100%

75.0%

and 0.810

respectively

of which Kwak TI-RADS were 78.0%

76.9%

77.6% and 0.775

respectively

and of whichKwak TI-RADS combined with BRAFV600 Egene mutation detection were 88.0%

84.6%

86.8%

0.873

respectively. Thesensitivity

specificity and accuracy of the combined application of Kwak Ti-RADS and BRAFV600 Egene mutation detection werenot statistically significant compared with the two applications alone.ConclusionFor indeterminate thyroid nodules withindeterminate cytological results

Kwak TI-RADS combined with BRAFV600 Egene mutation detection can certainly improve itsdiagnostic efficacy.

关键词

超声检查TI-RADSBRAFV600E基因突变甲状腺结节

Keywords

UltrasonographyTI-RADSBRAFV600E gene mutation detectionThyroid nodulebenign and malignant

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Application value of Kwak TI-RADS and BRAFV600E gene mutation detection in thyroid nodules with indeterminate cytological results

DOI：10.16245/j.cnki.issn1008-6978.2021.01.010

摘要

Abstract

关键词

Keywords

references

Application value of Kwak TI-RADS and BRAF^V600E gene mutation detection in thyroid nodules with indeterminate cytological results