ObjectiveTo analyze the left ventricular global systolic function with three-dimensional speckle tracking imaging（3 D-STI）in patients with type 2 diabetes mellitus（T2 DM）complicated with hyperuricemia（HU）.MethodsSixty-two patients with T2 DM were divided into T2 DM group（33 cases）and T2 DM+HU group（29 cases）according to whether they had HU

and 40 healthy subjects were selected as the control group.All groups were examined by routine and three-dimensional echocardiography.The 3 D-STI analysis software was used to obtain and compare the differences in 3 D-STI parameters between the groups

and the influencing factors were analyzed.ResultsLeft ventricular global longitudinal strain（GLS）in T2 DM group was lower than that in control group

and the difference was statistically significant（P<0.05）.There were no significant difference in left ventricular global circumscribed strain（GCS）

area strain（GAS）

and radial strain（GRS）between the T2 DM group and control group.GLS

GAS

GCS and GRS in T2 DM+HU group were lower than those in control group and T2 DM group

and the differences were statistically significant（all P<0.05）.Fasting blood glucose and serum uric acid were independent influencing factors of left ventricular global strain values in all directions.Conclusion3 D-STI can sensitively detect the impaired left ventricular global systolic function in patients with T2 DM complicated with HU at early stage

providing a reliable basis for clinical practice.