ObjectiveTo investigate the clinical value of contrast-enhanced ultrasound in the differential diagnosisof benign and malignant peripheral pulmonary focal lesions.MethodsOne hundred and sixteen cases of peripheral pulmonaryfocal lesions confirmed by pathology in our hospital were selected

including 62 benign lesions and 54 malignant lesions. Thephase and mode of contrast-enhanced ultrasound in benign and malignant lesions were compared.ResultsThe enhancementphase of benign lesions was dominated by early enhancement（82.3%）

while that of malignant lesions was dominated by lateenhancement（64.8%）.The difference was statistically significant（P<0.05）.The difference of contrast patterns between benignand malignant lesion was statistically significant（P<0.05）

in which the number of malignant lesions enhanced by piecewisepatch was higher than that of benign lesions

the difference was statistically significant（37 lesions vs. 23 lesions

P<0.05）. Thenumber of benign lesions with rapid basal dendritic enhancement was higher than that of malignant lesions

and the differencewas statistically significant（14 lesions vs. 3 lesions

P<0.05）. Combined with the features of contrast-enhanced ultrasound ofbenign and malignant lesions

the sensitivity

specificity and accuracy of contrast-enhanced ultrasound in the diagnosis ofmalignant lesions were 75.9%（41/54）

62.9%（39/62）and 69.0%（80/116）

respectively.ConclusionContrast-enhancedultrasound has a certain clinical value in the differential diagnosis of peripheral pulmonary focal lesions.