ObjectiveTo evaluate left ventricular diastolic function in patients with acute pulmonary embolismbefore and after thrombolysis by echocardiography.MethodsEighty-seven patients with pulmonary embolism confirmed bycomputed tomographic pulmonary angiography（CTPA）in our hospital were selected. All patients were examined by emergencyechocardiography on admission. According to left ventricular diastolic function

they were divided into 4 groups:normal diastolicfunction group（n=22）

reduced diastolic function grade Ⅰ group（n=31）

reduced diastolic function grade Ⅱ group（n=20）andreduced diastolic function grade Ⅲ group（n=14）. Pulmonary artery systolic pressure（PASP）

tricuspid regurgitation pressuregradient（TRPG）

anatomical morphological index of right heart and left ventricular diastolic function before and afterthrombolysis were compared among groups.The correlation between PASP and parameters of left ventricular diastolic functionbefore and after thrombolysis was analyzed.ResultsThe ratio of mitral valve early diastolic peak flow velocity（E）and the latediastolic peak flow velocity（E/A）

the ratio of E and mitral valve ring early diastolic peak velocity（E/e’）

the ratio of early andlate diastolic left ventricular filling rate（VER/VAR）

the ratio of the early and late diastolic left ventricular filling volume（VE/VA）were statistically different before thrombolysis among groups（all P<0.05）.After thrombolysis

the E/A in grade Ⅱand Ⅲ groups were significantly lower than those before thrombolysis（both P<0.05）.The E/e’in grade Ⅰ

Ⅱ

and Ⅲ groupsafter thrombolysis were significantly lower than those before thrombolysis

VER/VAR and VE/VA were significantly higher thanthose before thrombolysis

the differences were statistically significant（all P<0.05）. There was no statistically significantdifference in E/A before and after thrombolysis in the grade Ⅰ group.After thrombolysis

the PASP

TRPG

right ventricular enddiastolic diameter（RVED）

right ventricular anterior wall thickness（RVAWT）and main pulmonary artery inner diameter（PAD）of patients in each group were significantly lower than those before thrombolysis

and the differences were statistically significant（all P<0.05）. Before thrombolysis

PASP was positively and weakly correlated with E/A（r=0.293

P=0.031）

negativelycorrelated with VER/VAR and VE/VA（r =-0.450

-0.471

P=0.011

0.013）

moderately and positively correlated with E/e’（r=0.572

P=0.011）. After thrombolysis

PASP was positively and weakly correlated with E/A（r=0.107

P=0.039）

negativelyand weakly correlated with VER/VAR

VE/VA（r =-0.229

-0.235

P=0.037

0.036）

and positively and lowly correlated withE/e’（r=0.362

P=0.030）.ConclusionEchocardiography can evaluate the effect of thrombolytic therapy by evaluating leftventricular diastolic function in patients with acute pulmonary embolism.