ObjectiveTo evaluate the right ventricular systolic function of patients with end-stage renal disease（ESRD）with normal left ventricular ejection fraction（LVEF）by real-time three-dimensional echocardiography and three-dimensional speckle tracking imaging.MethodsA total of 43 ESRD patients with normal LVEF on regular hemodialysis in theblood purification center of our hospital were selected

which were divided into the ESRD group（23 cases）and the ESRD withpulmonary hypertension group（20 cases）according to whether they were combined with pulmonary hypertension. Twenty-fivehealthy volunteers were enrolled as the control group. The right atrium diameter（RAD）

right ventricular basal diameter（RVD1）

right ventricular mid diameter（RVD2）

right ventricular longitudinal diameter（RVD3）

pulmonary artery diameter（PAD）

LVEF and right ventricular index of myocardial performance（RIMP）were measured by conventional echocardiography.The right ventricular end diastolic volume（EDV）

right ventricular end systolic volume（ESV）

stroke volume（SV）

rightventricular output per minute（RVCO）

3 D right ventricular ejection fraction（3 DRVEF）

fractional area change（FAC）andtricuspid annular plane systolic excursion（TAPSE） were measured by real-time three-dimensional echocardiography. Theglobal longitudinal strain of free wall（3 DGLS）was obtained by three-dimensional speckle tracking imaging. The differences ofthe above parameters were compared

and the correlation between 3 DGLS and right ventricular systolic function was analyzed.ResultsCompared with the control group

EDV

ESV

RVCO

RIMP were increased in ESRD group

3 DRVEF

TAPSE

FACwere decreased（all P<0.05）.RVD1

RVD2

RVD3 in ESRD group were not statistically significant. RAD

RVD1

RVD2

PAD

SV were increased in ESRD with pulmonary hypertension group（all P<0.05）.Compared with the ESRD group

EDV

ESV andRVCO in the ESRD with pulmonary hypertension group were increased

while the 3 DRVEF

TAPSE

FAC were decreased（allP<0.05）. The absolute value of 3 DGLS decreased significantly in turn in ESRD group

ESRD with pulmonary hypertension groupand the control group（P<0.01）. Correlation analysis showed that the absolute value of 3 DGLS was strongly positively correlatedwith 3 DRVEF

TAPSE

FAC（r=0.77

0.62

0.59

all P<0.01）

and negatively correlated with RIMP value（r=-0.55

P<0.01）.ConclusionReal-time three-dimensional echocardiography and three-dimensional speckle tracking imaging can be appliedto evaluate the right ventricular systolic function of patients with LVEF-preserved ESRD.