Comparative analysis of computer-aided diagnosis system in the diagnosis of benign and malignant thyroid nodules based on different guidelines

YE Fengying; LI Shangqing; SU Qichen; YOU Jianhong; WANG Kangjian; CAI Mingli; LV Guorong

doi:10.16245/j.cnki.issn1008-6978.2020.09.019

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Comparative analysis of computer-aided diagnosis system in the diagnosis of benign and malignant thyroid nodules based on different guidelines

更新时间：2021-10-08

- Comparative analysis of computer-aided diagnosis system in the diagnosis of benign and malignant thyroid nodules based on different guidelines
- Journal of Clinical Ultrasound in Medicine Vol. 22, Issue 9, Pages: 694-696(2020)
- 作者机构：
  
  1. 福建医科大学附属第二医院超声科
  2. 厦门大学附属中山医院超声科
  3. 福建医科大学附属漳州市医院超声科
  4. 晋江市医院超声科
- 作者简介：
- 基金信息：
- DOI：10.16245/j.cnki.issn1008-6978.2020.09.019
  CLC： R736.1;R445.1
- Published：2020，
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[1]叶冯颖,李尚青,苏淇琛,游剑虹,王康健,蔡名利,吕国荣.计算机辅助诊断系统基于不同指南诊断甲状腺良恶性结节的对比分析[J].临床超声医学杂志,2020,22(09):694-696.

YE Fengying, LI Shangqing, SU Qichen, et al. Comparative analysis of computer-aided diagnosis system in the diagnosis of benign and malignant thyroid nodules based on different guidelines. [J]. Journal of Clinical Ultrasound in Medicine 22(9):694-696(2020)
[1]叶冯颖,李尚青,苏淇琛,游剑虹,王康健,蔡名利,吕国荣.计算机辅助诊断系统基于不同指南诊断甲状腺良恶性结节的对比分析[J].临床超声医学杂志,2020,22(09):694-696. DOI： 10.16245/j.cnki.issn1008-6978.2020.09.019.

YE Fengying, LI Shangqing, SU Qichen, et al. Comparative analysis of computer-aided diagnosis system in the diagnosis of benign and malignant thyroid nodules based on different guidelines. [J]. Journal of Clinical Ultrasound in Medicine 22(9):694-696(2020) DOI： 10.16245/j.cnki.issn1008-6978.2020.09.019.

摘要

目的对比分析计算机辅助诊断（CAD）系统基于不同指南诊断甲状腺良恶性结节的价值。方法多中心、前瞻性分析经手术或超声引导下细针穿刺病理证实的453例甲状腺结节患者（共521个甲状腺结节）

以病理结果为金标准

绘制CAD系统基于不同指南（ACR指南、ATA指南、AACE指南、KSThR共识、BTA指南、Kwak指南、Seo指南、Russ指南）诊断甲状腺恶性结节的受试者工作特征（ROC）曲线

计算曲线下面积（AUC）

分析其诊断效能。结果以2分为截断值

KSThR共识诊断甲状腺恶性结节的敏感性90.60%

阴性预测值84.1%

AUC为0.759

均高于其余7个指南（均P<0.01）;以分类4类为截断值

BTA指南诊断甲状腺恶性结节的特异性79.95%

阳性预测值70.9%

均高于其余7个指南（均P<0.01）。结论 CAD系统对甲状腺良恶性结节的鉴别诊断有较好价值

KSThR共识的AUC和敏感性最高

BTA指南的特异性最高。

Abstract

Objective To compare the diagnostic efficacy of computer-aided diagnosis（CAD）system based on different guidelines for the diagnosis of benign and malignant thyroid nodules.Methods A multicentric prospective study was conducted in 453 patients with 521 thyroid nodules

which were confirmed by pathology of surgery or ultrasound guided fine needle aspiration.Taken pathology as the gold standard

the receiver operating characteristic（ROC）curve of CAD system was obtained based on different guidelines（ACR guideline

ATA guideline

AACE guideline

KSThR consensus

BTA guideline

Kwak guideline

Seo guideline

Russ guideline）.The area under the curves（AUC）was calculated and the diagnostic efficiency was analyzed.Results When the cut-off value was 2 scores

the sensitivity

negative predictive value and AUC of KSThR consensus were 90.60%

84.1% and 0.759

respectively

which were higher than those of the other seven guidelines（all P<0.01）.When the cut-off value was grade 4

the specificity and positive predictive value of BTA guidelines in the diagnosis of thyroid malignant nodules were 79.95% and 70.9%

respectively

which were higher than the other seven guidelines（all P<0.01）.Conclusion The diagnostic efficay of CAD system in the diagnosis of benign and malignant thyroid nodules is satisfying.The KSThR consensus has the highest AUC and sensitivity

and the BTA guidelines has the highest specificity.

关键词

超声检查计算机辅助诊断甲状腺结节良恶性诊断效能

Keywords

UltrasonographyComputer-aided systemThyroid nodulebenign and malignantDiagnostic efficacy

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